Furosemide Injection T P Dosage/Direction for Use

Unless otherwise prescribed by the physician, the initial dose for adults and adolescents of ≥15 years is 20-40 mg Furosemide Injection IV or IM. If after a single dose of 20-40 mg Furosemide Injection, the diuretic effect is not satisfactory, the dose may be stepwise increased at 2-hourly intervals by 20 mg each time, until satisfactory diuresis is obtained. The individual dose thus established should then be given once or twice daily.
Acute Pulmonary Oedema: An initial dose of 40 mg Furosemide Injection is administered IV. If the patient's condition requires it, a further dose of 20-40 mg Furosemide Injection is injected after 20 minutes.
Forced Diuresis: 20-40 mg Furosemide Injection is given in addition to infusion of electrolyte solution. Further treatment depends on the elimination of urine and must include substitution of the fluid and electrolyte losses. In poisoning with acid or basic substances, the elimination rate can be further increased by alkalisation or acidification, respectively, of the urine.
Infants and Children <15 years: Parenteral administration (if necessary, continuous drip infusion) is indicated only in life-threatening conditions. For IV or IM injection, the dosage schedule is 1 mg furosemide/kg body weight up to a daily maximum of 20 mg Furosemide Injection. Therapy should be changed to oral administration as soon as possible.
Administration: IV or IM administration of Furosemide Injection 20 mg is indicated in all causes where intestinal adsorption is impaired or rapid fluid elimination is necessary. IV Furosemide Injection 20 mg should be injected slowly. The rate of injection of 4 mg/minute should not be exceeded. During long-term treatment, serum creatinine and urea and also plasma electrolytes, in particular potassium, calcium, chloride and bicarbonate, should be regularly checked.
Furosemide, being an anthranilic acid derivative, dissolves in alkaline media with salt formation. The solution for parenteral application contains the sodium salt of the carboxylic acid without a solubilizer. The solution has a pH of about 9 but no buffer capacity, which means that the drug may precipitate at pH values <7. If the ready-to-use solution has a pH from weakly alkaline to neutral, the mixtures may be used for up to 24 hours. Furosemide Injection 20 mg must not be mixed with other drugs in the same injection syringe. The duration of treatment is at the physician's discretion.
Special Note: Although administration of Furosemide Injection only rarely leads to hypokalaemia, a potassium-rich diet (lean meat, potatoes, bananas, tomatoes, cauliflower, spinach, dried fruits, etc.) is always advisable. Occasionally, treatment with potassium-containing or potassium-sparing preparations may be indicated.